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  • 媒體科大

    人民網:CAR-T治療白血病“中國案例”成功誕生

    發布者:新聞中心發布時間:2019-01-31瀏覽次數:10

        人民網武漢1月31日電 1月30日,武漢科技大學生命科學與健康學院院長、武漢波睿達生物科技有限公司董事長張同存教授收到喜訊,患白血病的迪拜女孩麥吉來漢復查,結果顯示:癌細胞繼續消失,體內CAR-T細胞持續存在。這表明,CAR-T治療白血病“中國案例”成功誕生。

        三年前,患急性淋巴細胞白血病的21歲女孩麥吉在輾轉迪拜、新加坡、印度、菲律賓等國治療,骨髓移植后再次復發。絕望之際獲知武漢波睿達生物科技有限公司和武漢同濟醫院血液科聯合進行CAR-T臨床試驗研究的注冊信息后,立即來漢求治。

        張同存教授團隊為麥吉精心制備了CAR-T,武漢同濟醫院醫務人員將CAR-T輸入她體內。三年來,她定期復查,病情持續緩解。這次復查距離治療已有三年,復查結果顯示,麥吉體內的白血病細胞已經消失,體內的CAR-T細胞持續存在。這標志著麥吉的白血病獲得臨床治愈。

        CAR-T療法先采集病人的血液,在實驗室分離出T淋巴細胞,然后應用基因工程技術,變身為能識別并殺滅腫瘤的CAR-T細胞,再輸回病人體內。CAR-T細胞仿佛一個個帶著GPS導航的殺手,殺滅腫瘤后進入休眠狀態,一旦發現新的腫瘤細胞,會再次被激活并發動攻擊。

        張同存教授從美國人類健康與環境效應研究所博士后出站后,2007年加盟武漢科技大學,成為國內最早從事CAR-T研究的學者之一。2014年成立武漢波睿達生物科技有限公司,致力于CAR-T技術的產業化和新藥研發。目前,已完成急性淋巴細胞白血病、淋巴瘤和多發性骨髓瘤臨床試驗研究近400例,急性淋巴細胞白血病完全緩解率達90%,淋巴瘤患者治療有效率90%,多發性骨髓瘤患者完全緩解率在70%以上,獲得了國內外領先的臨床療效。(程毓 攝影方斌)

        http://hb.people.com.cn/n2/2019/0131/c192237-32600522.html

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