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  • 媒體科大

    科技日報:2018年中國醫藥生物技術十大進展

    發布者:新聞中心發布時間:2019-01-25瀏覽次數:10

      近日,中國醫藥生物技術協會揭曉了2018年“中國醫藥(600056,股吧)生物技術十大進展”,該十大進展具有技術創新性突出、經濟效益或社會效益顯著、推動行業科技進步作用明顯等特點。

      1.全球消滅脊灰行動計劃關鍵疫苗獲國際認證

      國家一類新藥新型脊灰疫苗(sIPV、bOPV)獲國際認證。bOPV是“中國生物”首個研發上市,通過WHO預認證,與聯合國兒童基金會達成長期采購協議。sIPV產品擁有自主知識產權,首創采用基于片狀載體的生物反應器培養系統,在國際上率先解決逐級放大的技術難題,填補了國內空白。

      2.國產PD-1單抗相繼獲批上市

      PD-1單抗相繼獲批上市。君實生物的“特瑞普利單抗注射液”用于治療全身系統治療失敗后不可切除或轉移性黑色素瘤;信達生物的PD-1單抗(信迪利單抗注射液)用于經二線系統化療復發或難治性經典型霍奇金淋巴瘤。

      3.重組細胞因子基因衍生蛋白注射液獲批上市

      生物新藥——重組細胞因子基因衍生蛋白注射液獲批上市。該產品是用于乙肝治療、在人體天然免疫調節蛋白分子結構基礎上,進行氨基酸序列系統改造獲得的新型高效人體免疫功能調節蛋白分子藥物。

      4.分子診斷相關產品獲批上市

      一批新型分子診斷設備和試劑盒獲批上市,包括用于檢測腫瘤患者外周血中CTC的數量的自動化循環腫瘤細胞捕獲設備;用于肝癌早篩早診的家用愛福陪檢測試劑盒和血漿microRNA聯合試劑盒;用于大腸癌輔助診斷的人類 SDC2 基因甲基化檢測試劑盒等。

      5.免疫細胞治療取得新進展

      我國免疫細胞治療管理規范出臺;共有31個免疫細胞產品獲得國家藥品審評中心受理,其中7個免疫細胞產品獲得臨床試驗批準;基于腫瘤新生抗原的個體化疫苗用于晚期肺癌等惡性腫瘤的治療進入臨床研究。

      6.干細胞臨床研究取得初步進展

      人牙髓間充質干細胞注射液等5款干細胞產品臨床試驗申請獲得國家藥品審評中心受理;全長牙髓再生的臨床研究獲得成功。

      7.干細胞基礎研究有所突破

      中國科學院上海營養與健康研究院采用可變色熒光蛋白建立了造血干細胞標記系統,首次揭示了體內造血干細胞歸巢微環境的獨特微血管結構,發現了一種全新的微環境細胞——先導細胞。武漢科技大學結合干細胞與基因療法,采用“兩步法”的策略使先天性眼盲的小鼠產生了視覺反應。

      8.組織工程“人耳”首次在人體培育成功

      上海交通大學和北京整形外科醫院從患有小耳畸形的兒童患者未完全發育的耳朵中移取軟骨細胞,種植在3D打印的耳朵模型支架上,首次在患兒身上制造出了新的耳朵。

      9.實驗動物研究關鍵技術取得重要突破

      中科院研究人員從體細胞克隆出兩只基因完全相同的獼猴,突破了現有技術無法克隆靈長類動物的難題;通過刪除單倍體胚胎干細胞印記基因修飾,并利用該細胞進行復雜胚胎操作的形式,得到了世界上首只雙父親來源的小鼠;利用基因編輯和體細胞核移植技術,成功培育出世界首例亨廷頓舞蹈病基因豬。

      10.人工染色體構建技術取得重要進展

      中科院成功將單細胞真核生物釀酒酵母天然的十六條染色體人工創建為具有完整功能的單條染色體,表明天然復雜的生命體系可以通過人工設計變為更簡單的體系;天津大學對自主設計合成的5號釀酒酵母環形染色體進行基因組重排,為探索環形染色體結構變異和功能提供了新的研究思路和模型。

        http://news.hexun.com/2019-01-25/195990768.html


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